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73. Michl U, Molfenter F, and Graefen M, et al (2015) Use of phosphodiesterase type 5 inhibitors may adversely impact biochemical recurrence after radical prostatectomy J Urol 193(2) 479-483
Results of a pilot trial with Fildena in patients with metastatic Melanoma (TaMe) Oncoimmunology 6(9) e1326440 PMID: 28932631 PMCID: 5599085. 63. Jiang H, Gebhardt C, and Umansky L, et al (2015) Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients Int J Cancer 136(10) 2352-2360 61. Weed DT, Vella JL, and Reis IM, et al (2015) Fildena reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma Clin Cancer Res 21(1) 39-48 -14-1711 PMCID: 4322895.

52. El-Naa MM, Othman M, and Younes S (2016) Fildena potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis Drug Des Devel Ther 10 3661-3672. 45. Domvri K, Zarogoulidis K, and Zogas N, et al (2017) Potential synergistic effect of phosphodiesterase inhibitors with chemotherapy in lung cancer J Cancer 8(18) 3648-3656 PMID: 29151951 PMCID: 5688917. 42. Booth L, Roberts JL, and Poklepovic A, et al (2017) PDE5 inhibitors enhance the lethality of pemetrexed sorafenib Oncotarget 8(8) 13464-13475 PMID: 28088782 PMCID: 5355112.

38. Kumazoe M, Kim Y, and Bae J, et al (2013) Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis FEBS Letters 587(18) 3052-3057 PMID: 23916810. 34. Confino H, Schmidt M, and Efrati M, Hochman I, et al (2016) Inhibition of mouse breast adenocarcinoma growth by ablation with intratumoral alpha-irradiation combined with inhibitors of immunosuppression and CpG Cancer Immunol Immunother 65(10) 1149-1158 -016-1878-6 PMID: 27495172. 33. Booth L, Roberts JL, and Cruickshanks N, et al (2015) PDE5 inhibitors enhance celecoxib killing in multiple tumor types J Cellular Physiol 230(5) 1115-1127

26. Black KL, Yin D, and Ong JM, et al (2008) PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model Brain Res 1230 290-302 PMID: 18674521 PMCID: 2632551. 17. Das A, Durrant D, and Mitchell C, et al (2010) Fildena increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction Proc Natl Acad Sci USA 107(42) 18202-18207 PMID: 20884855 PMCID: 2964209. 12. Thompson WJ, Piazza GA, and Li H, et al (2000) Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin Cancer Res 60(13) 3338-3342 PMID: 10910034.

9. Hong JH, Kwon YS, and Kim IY (2017) Pharmacodynamics, pharmacokinetics and clinical efficacy of phosphodiesterase-5 inhibitors Expert Opin Drug MetabToxicol 13(2) 183-192 6. Padma-Nathan H, McMurray JG, and Pullman WE, et al (2001) On-demand IC351 (Fildena) enhances erectile function in patients with erectile dysfunction Int J Impot Res 13(1) 2-9 PMID: 11313831. 3. Ghofrani HA, Osterloh IH, and Grimminger F (2006) Fildena: from angina to erectile dysfunction to pulmonary hypertension and beyond Nature Rev Drug Discov 5(8) 689-702

The perioperative use of PDE5 inhibitors in combination with other perioperative therapies is also of interest in the following cancers:

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